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Retatrutide -developed by pharmaceutical giant Eli Lilly and alternatively known as GGG Tri-agonist, GLP-1/GIP/glucagon tri-agonist, or LY3437943-is an injectable breakthrough poised for FDA approval, with significant potential to treat obesity and diabetes. While it shares similarities with established weight loss therapies like tirzepatide and semaglutide, retatrutide delivers enhanced efficacy. When paired with balanced nutrition, consistent physical activity, and healthy lifestyle adjustments, it not only amplifies weight loss results but also addresses obesity-related comorbidities such as diabetes and hypertension (high blood pressure).
What sets retatrutide apart from other weight loss medications is its superior effectiveness, driven by three key therapeutic mechanisms:
**Gastric Inhibitory Polypeptide Receptor (GIPR) Agonism: By activating GIP receptors, retatrutide strengthens appetite control, blocks fat storage, reduces caloric intake, and boosts energy expenditure.
**Glucagon-Like Peptide 1 Receptor (GLP-1R) Agonism: It supports weight reduction by improving glycemic control-stimulating pancreatic insulin secretion while curbing the release of glucagon, a hormone that elevates blood sugar levels.
**Glucagon Receptor (GR) Agonism**: Retatrutide further regulates blood glucose by suppressing glucagon release, diminishes food cravings, and increases energy burn, all of which contribute to meaningful weight loss.
Product Specifications
| Parameter | Value |
|---|---|
| Products Name | Retatrutide |
| Trade Name | LY-3437943 |
| CAS No. | 2381089-83-2 |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | 4731.33g/mol |
| Sequence | Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{ α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| Appearance | White Lyophilized powder |
| Reconstitution | Required |
| Storage | After reconstitution store at 2°C - 8°C |
BENEFITS OF GLP-1 AGONISTS
Slows gastric emptying to prolong feelings of fullness
Suppresses excessive hepatic glucose production (prevents the liver from overproducing sugar)
Stimulates pancreatic insulin secretion in response to elevated blood glucose levels
Aids in glycemic control and blood sugar regulation
Alleviates hyperglycemia, particularly postprandial (after-meal) spikes
Reduces fasting insulin concentrations and fasting blood glucose levels
Lowers hemoglobin A1c (HbA1c) to improve long-term glycemic outcomes
Curbs appetite and reduces caloric consumption, while counteracting weight gain
Demonstrates efficacy in lowering triglyceride levels and mitigating oxidative stress associated with high LDL ("bad" cholesterol)
Promotes weight loss in obese patients when administered at higher dosages
Decreases leptin levels and enhances leptin sensitivity (improving the body's ability to regulate hunger and metabolism)
Facilitates the browning of white adipose tissue (converts energy-storing white fat to energy-burning brown fat)
Company profile
Guangsheng Technology Co., Ltd. We strive for survival, innovation and development through quality. We adhere to the business philosophy of honesty and trustworthiness, uphold the quality policy of "all based on quality standards, with customer satisfaction as the goal, pursuing novelty and people-oriented quality", and continuously improve and perfect ourselves. We are the developers and leaders of green active materials. Professional product production, product transportation and professional team services have enabled us to gain a good reputation worldwide.
Safety & Compliance Guidelines
For laboratory research use only. Not for human consumption, cosmetic use, therapeutic purposes, or veterinary applications.
Handle with standard laboratory protective equipment (gloves, lab coat, safety goggles) to avoid direct contact with skin, mucous membranes, or eyes.
In case of accidental exposure, rinse the affected area thoroughly with water. Seek medical advice if irritation, redness, or discomfort persists.
Dispose of unused peptide powder, reconstituted solution, and associated waste materials in accordance with local chemical waste disposal regulations for laboratory reagents.
service
1. We supply Peptides, APIs & Intermediates and so on to satisfy your needs;
2. We will reply you for your inquiry in 24 hours;
3. Strictly on selecting raw materials . Our Q&C team will inspect every product quality strictly before delivery;
4. Reasonable & competitive price, fast lead time ;
5. After delivery, we will track the products for you once every two days, until you get the products. When you got the goods, if you have any questions about the problem, contact with us, we will offer the solve way for you ;
6. 100% safe delivery, guaranteed delivery .
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