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Melanotan I is a research-grade synthetic peptide analog of α-melanocyte-stimulating hormone (α-MSH), designed exclusively for controlled laboratory studies on melanocortin receptor signaling, pigmentation regulation, and related physiological pathways. Supplied as a sterile lyophilized powder, it is not approved for human or veterinary use, nor is it intended for any therapeutic, cosmetic, or consumer applications.
Core Properties & Formulation
Melanotan I mimics the biological activity of endogenous α-MSH by selectively binding to melanocortin receptors (primarily MC1 receptors expressed on melanocytes). Its core amino acid sequence is Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂, a 13-residue peptide engineered to enhance receptor affinity and resistance to enzymatic degradation compared to natural α-MSH. This structural optimization makes it a valuable tool for investigating receptor-ligand interaction dynamics in preclinical models.
Purity: Research-grade Melanotan I has a purity of ≥98%, verified by high-performance liquid chromatography (HPLC) and mass spectrometry (MS).
Solubility: Water-soluble after reconstitution with sterile solvent (e.g., sterile water, phosphate-buffered saline); forms a clear, colorless solution at typical research concentrations.
Stability: Exhibits stable chemical properties under recommended storage conditions; no significant degradation observed when handled properly.
Unreconstituted Powder: Store at -20°C in a desiccated, light-protected airtight container to prevent peptide oxidation and degradation. Avoid exposure to high temperatures, humidity, and direct sunlight.
Reconstituted Solution: After mixing with sterile solvent, store the solution at 2–8°C and use within 24–48 hours. Repeated freeze-thaw cycles are strictly prohibited, as this can disrupt peptide structure and reduce biological activity.
Handling Notes: Aliquot the lyophilized powder into smaller portions before storage to minimize repeated opening of the primary container, which helps maintain long-term stability.
Mechanism for Research Applications
Melanotan I is utilized in laboratory studies to explore melanocortin receptor-mediated biological processes, with the following research-focused mechanisms:
MC1 Receptor Activation: Binds to MC1 receptors on melanocytes to stimulate intracellular signaling cascades, including cyclic adenosine monophosphate (cAMP) production and protein kinase A (PKA) activation. This pathway is studied to understand its role in melanin synthesis and pigmentation regulation in cellular and animal models.
Receptor Specificity Studies: Serves as a selective probe to distinguish the functions of MC1 receptors from other melanocortin receptor subtypes (e.g., MC3, MC4). Researchers use it to investigate receptor-specific effects on physiological processes such as energy metabolism and inflammation in controlled experimental settings.
Peptide Structure-Activity Relationship (SAR) Research: Its defined sequence and receptor affinity make it a benchmark for developing novel melanocortin analogs with modified pharmacokinetic properties, such as prolonged half-life or enhanced receptor selectivity.
Key Research Applications
Pigmentation & Melanocyte Biology Research: Applied in studies on melanin synthesis pathways, melanocyte proliferation, and the role of MC1 receptors in skin pigmentation regulation. Suitable for cellular experiments investigating the effects of peptide stimulation on melanin production.
Melanocortin Receptor Signaling Studies: Used to explore the molecular mechanisms of melanocortin receptor activation and downstream signaling cascades, providing insights into receptor function in various tissues and cell types.
Peptide Formulation & Stability Research: Employed to evaluate the storage stability, solubility, and bioactivity retention of peptide formulations, supporting the development of research-grade peptide blends and delivery systems.
Preclinical Pharmacology Models: Utilized in animal models to investigate the in vivo effects of MC1 receptor activation, with a focus on understanding physiological responses rather than therapeutic outcomes.
Safety & Compliance Guidelines
For laboratory research use only. Not for human consumption, cosmetic use, therapeutic purposes, or veterinary applications.
Handle with standard laboratory protective equipment (gloves, lab coat, safety goggles) to avoid direct contact with skin, mucous membranes, or eyes.
In case of accidental exposure, rinse the affected area thoroughly with water. Seek medical advice if irritation, redness, or discomfort persists.
Dispose of unused peptide powder, reconstituted solution, and associated waste materials in accordance with local chemical waste disposal regulations for laboratory reagents.
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