Ruypeptide Biotechnology Co., Ltd. is one of the most reliable manufacturers and suppliers of high purity ahk-cu in China. If you're going to buy high quality high purity ahk-cu made in China, welcome to get quotation from our factory. Also, discount information is available.
AHK-Cu is a premium copper-binding tripeptide (sequence: Ala-His-Lys-Cu, CAS: 682809-81-0) with ≥99% HPLC purity, available as blue lyophilized powder. It stimulates collagen/elastin synthesis, accelerates wound healing, and exerts anti-inflammatory/antioxidant effects for skin anti-aging. It also promotes hair follicle growth by extending the anagen phase, aiding hair loss research. Water-soluble and stable at -20℃, this research-grade peptide is ideal for dermatological, trichological, and regenerative medicine applications.
Molecular & Physical Properties
Amino Acid Sequence
Ala-His-Lys-Cu, formed by chelating the tripeptide alanyl-histidyl-lysine with copper ions.
Purity
≥99% (HPLC verified), ensuring high bioactivity and minimal impurities.
Physical Appearance
Deep blue lyophilized powder, highly water-soluble for easy formulation into solutions, creams, or injectables.
Stability
Optimal storage at -20℃; stable for 24 months when sealed from light and moisture; avoid high temperatures to prevent copper ion dissociation.
Core Biological Mechanisms
Collagen & Elastin Synthesis
It upregulates the expression of TGF-β and matrix metalloproteinase inhibitors (TIMPs), stimulating fibroblasts to produce type I/III collagen and elastin. This enhances skin elasticity, reduces fine lines, and improves skin texture.
Antioxidant & Anti-inflammatory Effects
The copper ion moiety scavenges free radicals (e.g., superoxide anion, hydroxyl radicals) to mitigate oxidative stress. It also inhibits NF-κB pathways, reducing the release of pro-inflammatory cytokines (TNF-α, IL-6) and alleviating tissue inflammation.
Hair Follicle Activation
It extends the anagen (growth) phase of hair follicles, increases dermal papilla cell proliferation, and improves microcirculation around hair follicles, which aids in reversing hair miniaturization associated with androgenetic alopecia.
Wound Healing Acceleration
By promoting angiogenesis and fibroblast migration, it speeds up granulation tissue formation and epithelialization, shortening recovery time for acute and chronic wounds (e.g., burns, diabetic ulcers).
Application Scenarios
Dermatological Cosmetics
Added to anti-aging serums, creams, and masks to improve skin firmness, fade wrinkles, and repair photodamaged skin.
Trichological Research
Used in topical formulations or scalp injections for androgenetic alopecia treatment and hair regrowth studies.
Regenerative Medicine
Applied in wound care dressings and tissue engineering scaffolds to enhance skin and soft tissue repair.
Laboratory Research
Serves as a tool compound for studying copper peptide biology, oxidative stress, and tissue regeneration mechanisms.
Safety & Advantages
Non-immunogenic, with no reported allergic reactions or systemic side effects in topical use.
Biodegradable, breaking down into natural amino acids and copper ions that are metabolized by the body.
Compatible with most cosmetic and pharmaceutical excipients (e.g., hyaluronic acid, glycerin), suitable for multi-component formulations.
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