Melanotan-II has poor solubility in water but exhibits good solubility in organic solvents such as dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF).

In practical applications, if dissolution is required for experimental or therapeutic purposes, it can first be dissolved in DMSO to prepare a high-concentration stock solution and subsequently diluted with an appropriate buffer (such as physiological saline or phosphate-buffered saline). However, care must be taken to control the final concentration of DMSO-generally keeping it below 0.1%-to avoid toxic effects on cells or the organism.

In the field of aesthetics, Melanotan-II has attracted widespread attention due to its ability to induce melanin production and darken the skin. Numerous studies have focused on evaluating its efficacy and safety regarding sun protection and cosmetic use.